Search results for "QT prolongation"

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Changes of QTc interval after opioid switching to oral methadone.

2013

Abstract A consecutive sample of patients who were switched from strong opioids to methadone in a period of 1 year was surveyed. QTc was assessed before switching (T0) and after achieving adequate analgesia and an acceptable level of adverse effects (Ts). Twenty-eight of 33 patients were switched to methadone successfully. The mean initial methadone doses at T0 were 67.1 mg/day (SD ±80.2, range 12-390). The mean QTc interval at T0 was 400 ms (SD ±30, range 330-450). The mean QTc interval at Ts (median 5 days) was 430 ms (SD ±26, range 390-500). The difference (7.7 %) was significant (p < 0.0005). Only two patients had a QTc of 500 ms. No serious arrhythmia was observed. At the linear regres…

MaleRiskCancer pain; Methadone; QT prolongation; Toxicity; Opioid switchingPainSettore MED/41 - AnestesiologiaQT prolongationSettore MED/42 - Igiene Generale E ApplicataQT intervalCONSECUTIVE SAMPLEElectrocardiographyNeoplasmsOpiate Substitution TreatmentmedicineHumansIn patientcardiovascular diseasesCancer painAdverse effectAgedToxicitybusiness.industryMiddle AgedAnalgesics OpioidLong QT SyndromeOncologyOpioidAnesthesiaToxicityLinear Modelscardiovascular systemOpioid switchingFemaleCancer painbusinessMethadoneMethadonemedicine.drug
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